pyrogens, suchas microbial products and cytokines, trigger release of PGE2 on the brain side of cipillary epithelium in hypothalamus. PGE2 triggers cAMP release from glial cells, which in turn activates nerve endings of hypothalamus neurons…
looks like a well designed pathway to adjust the set point of body temperature in response to pyrogens… this pathway seems too sophisticated to be a spill over or something….
but what is the pathway for?